Climate Change Data

Environmental Metrics

ESG Focus Areas

• Patients
• Employees
• Our Communities & World
• Ethics & Values

Environmental Achievements

• Completed lab renovation project utilizing energy-efficient cold storage equipment, updated LED lighting technologies, and added HVAC efficiencies to reduce energy demand outside of normal working hours.
• Saved over 100,000 plastic bottles from being landfilled through water use reduction initiatives and single-stream recycling programs.
• Successfully attained a Low Flow, Low Pollutant Sewer Use Discharge permit in 2021.

Social Achievements

• Developed myAgios Patient Support Services, providing a single point of engagement for patients and prescribers for prescription and access support.
• Launched a no-cost next-generation sequencing testing program called Anemia ID, expanded in 2021 to also provide genetic counseling.
• Established the first international PK deficiency patient advocacy advisory council (AAC).
• Improved DE&I at Agios as demonstrated by companywide surveys from 2018 and 2021.
• Organized a Season of Service in 2021, serving 4 charitable organizations and donating nearly $12,000.
• Achieved AAALAC accreditation for their animal research facility in early 2022.

Governance Achievements

• Maintained several policies and procedures that describe employees’ responsibilities for accessing computerized systems, handling data and information, and reporting cybersecurity events.
• Implemented a single source of truth for all employees and non-employees via their multi-year Identity & Access Management Program.
• Improved year-over-year in employee cybersecurity metrics through improved cybersecurity awareness training.

Climate Goals & Targets

Environmental Challenges

• Supply chain disruptions due to the COVID-19 pandemic
• Ensuring patient safety and well-being during clinical trials amidst the COVID-19 pandemic

Mitigation Strategies

• Established a clinical trial task force to ensure the safety of patients in clinical trials and support patients to enable their continued participation in studies.
• Managed more than 750 patient requests during the COVID-19 pandemic, allowing for at-home study visits, investigational medicines shipped to patients, telemedicine approaches, and the use of local laboratories.
• Became a founding member of Decentralized Trials Research Alliance (DTRA) to accelerate the adoption of patient-focused, decentralized clinical trials.

Supply Chain Management

Responsible Procurement

• Serialization practices implemented to prevent counterfeiting

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: SASB, UN SDGs

Awards & Recognition

• 2021 TOP 100 Women-Led Business
• 2021 Gallagher Best-in-Class Employer for Employee Benefits
• Barron’s Top 100 Sustainable Companies 2020
• 2014 World Economic Forum Technology Pioneer
• FierceBiotech’s 2009 Fierce 15
• 2020 Women on Boards “W” Winning Company
• New England Venture Capital Association’s 2018 NEVY Awards Patient Impact Award Finalist
• 2021 Citeline Award for Excellence in Rare Disease Drug Development

Environmental Metrics

ESG Focus Areas

• Patient Access
• Health Equity
• Diversity & Inclusion
• Environmental Stewardship
• Ethical Business Practices

Environmental Achievements

• Completed sustainability projects such as building a bike storage unit, lab renovation with energy-efficient equipment, and LED lighting updates.
• Saved over 125,000 plastic bottles from landfill through water use reduction initiatives and single-stream recycling programs.

Social Achievements

• Launched myAgios® Patient Support Services providing copay assistance, free product for uninsured/underinsured patients, and global access programs.
• Involved caregivers of PK deficiency patients in the design of pediatric clinical trials.
• Partnered with sickle cell warriors to design a clinical trial, including branding and recruitment campaign.
• Improved DE&I metrics based on companywide surveys from 2018 and 2022.
• Achieved AAALAC accreditation for animal research facility.

Governance Achievements

• Established a cross-functional ESG working group with oversight from the Executive Team and Board of Directors.
• Maintained a Code of Business Conduct & Ethics, ensuring ethical marketing and interactions with healthcare professionals.
• No monetary losses from legal proceedings associated with false marketing claims or corruption/bribery.

Climate Goals & Targets

Environmental Challenges

• Not disclosed

Mitigation Strategies

• Not disclosed

Supply Chain Management

Supplier Audits: Not disclosed

Responsible Procurement

• Not disclosed

Climate-Related Risks & Opportunities

Physical Risks

• Not disclosed

Transition Risks

• Not disclosed

Opportunities

• Not disclosed

Reporting Standards

Frameworks Used: SASB (Biotechnology and Pharmaceuticals Industry), UN SDGs

Certifications: AAALAC

Third-party Assurance: Not disclosed

UN Sustainable Development Goals

• Not disclosed

Aligned with UN SDGs

Sustainable Products & Innovation

• Not disclosed

Awards & Recognition

• FierceBiotech’s 2009 Fierce 15, 2014 World Economic Forum Technology Pioneer, Biospace 2023 Best Places To Work, Cohn-Reznick ESG Gamechanger to Watch Award, Gallagher Best-in-Class EMPLOYER FOR EMPLOYEE BENEFITS, New England Venture Capital Association’s 2018 NEVY Awards PATIENT IMPACT AWARD, Pharma Intelligence's SCRIP Award for Best New Drug and Community Partnership of the Year, Citeline Award for Excellence in Rare Disease Drug Development, Women on Boards “W” WINNING COMPANY, Fierce Pharma's Marketing Awards, Barron’s TOP 100 SUSTAINABLE COMPANIES