Climate Change Data

Environmental Metrics

ESG Focus Areas

• Climate Change
• Waste Management

Climate Goals & Targets

Supply Chain Management

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: CDP Climate Change Questionnaire, WBCSD/WRI GHG Protocol (2004, as updated January 2015)

Third-party Assurance: ERM Certification and Verification Services, Inc.

Environmental Metrics

ESG Focus Areas

• Environmental
• Safety

Climate Goals & Targets

Supply Chain Management

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: WBCSD/WRI GHG Protocol (2004, as updated January 2015), OSHA Injury and Illness Recordkeeping and Reporting definitions

Third-party Assurance: ERM Certification & Verification Services Incorporated

Environmental Metrics

ESG Focus Areas

• Improve the Lives of People With Serious Diseases
• Foster a Culture of Innovation, Integrity and Inclusion
• Carefully Manage Our Operations and Environmental Footprint
• Make a Positive Impact in the Communities Where We Are Located

Environmental Achievements

• 53% reduction in absolute greenhouse gas (GHG) emissions since 2014
• 82% green-certified square footage in our buildings
• 100% renewable energy at our International Headquarters and R&D facility in the U.K.
• A- score on 2023 Climate Change survey for demonstrating environmental leadership

Social Achievements

• Expanded access to our CF medicines for more people around the world, with more than 60 countries where our medicines are reimbursed or accessible
• Strengthened our engagement with patient organizations
• Continued focus on recruiting, retaining and developing highly talented employees from a diverse range of backgrounds, promoting our employees’ continued well-being and professional development, and nurturing our unique culture
• $42+ million in charitable giving by Vertex and the Vertex Foundation
• 60% of employees volunteered during annual Global Day of Service

Governance Achievements

• 100% of employees completed annual code of conduct training
• 6 out of 11 Board directors are women and/or from underrepresented ethnic and racial groups
• New third-party risk management approach to more efficiently and effectively identify, mitigate and manage ongoing risk with third parties

Climate Goals & Targets

Environmental Challenges

• Increased cost for raw materials and scarcity of natural resources
• Potential impacts of drought on our locations in California and coastal flooding near our key facilities in Boston’s Seaport District

Mitigation Strategies

• Business continuity strategies and existing mitigation processes, including use of flood barriers, waterproofing, watertight doors and storm-resistant glass
• Decarbonization study at three of our largest research and manufacturing locations to identify opportunities to electrify these facilities and reduce our global GHG footprint

Supply Chain Management

Responsible Procurement

• Supplier Code of Conduct

Climate-Related Risks & Opportunities

Physical Risks

• Drought
• Coastal flooding

Transition Risks

• Increased cost for raw materials and scarcity of natural resources

Reporting Standards

Frameworks Used: SASB

Certifications: LEED, BREEAM, SKA, Fitwel, My Green Lab

Third-party Assurance: ERM CVS

Awards & Recognition

• LEED Platinum certification for Jeffrey Leiden Center
• Award of Merit for Interior/Tenant Improvement from Engineering News-Record New England