Climate Change Data

Environmental Metrics

Climate Goals & Targets

Supply Chain Management

Climate-Related Risks & Opportunities

Environmental Metrics

ESG Focus Areas

• Environmental
• Social
• Governance

Environmental Achievements

• Reduced waste through reuse of packaging materials and recycling of paper, hard plastic, and cardboard; switched from plastic tape to paper tape for packing shipments.
• Installed electric vehicle charging stations at corporate headquarters (planned for 2021).

Social Achievements

• Donated PPE and supplies to hospitals and non-profit organizations.
• Initiated a global clinical trial to evaluate selinexor as a potential treatment for COVID-19.
• Provided employees with meal vouchers and resources to support remote work.
• Offered a comprehensive benefits package including medical, dental, vision, life insurance, and retirement plans.
• Implemented training, development, and engagement programs including annual goal setting, employee engagement surveys, and stock-award recognition.
• Engaged in dialogue on diversity initiatives.
• Offered mentorship and paid internship programs.
• Sponsored local youth programs.
• Made annual charitable donations.
• Offered free learning webinars to communities.
• Supported a company-wide volunteer program.
• Launched KaryForward patient support program providing assistance with insurance coverage, copay assistance, and nurse case management.

Governance Achievements

• Developed a comprehensive compliance program with a Chief Compliance Officer reporting directly to the General Counsel and having access to the Board of Directors.
• Established a Compliance Committee to oversee healthcare-related regulatory and compliance matters.
• Implemented annual compliance training for all employees on the Code of Ethics and Business Conduct, including anti-harassment and anti-discrimination training.
• Developed a policy dedicated to the Foreign Corrupt Practices Act and Anti-Corruption.
• Established a Compliance Hotline for anonymous reporting.
• Adopted a Code of Ethics and Business Conduct, Corporate Governance Guidelines, and charters for various committees.
• Maintained a predominantly independent Board of Directors with diverse skills, experience, and backgrounds.

Climate Goals & Targets

Environmental Challenges

• Not disclosed

Mitigation Strategies

• Not disclosed

Supply Chain Management

Supplier Audits: Not disclosed

Responsible Procurement

• Not disclosed

Climate-Related Risks & Opportunities

Physical Risks

• Not disclosed

Transition Risks

• Not disclosed

Opportunities

• Not disclosed

Reporting Standards

Frameworks Used: Null

Certifications: Null

Third-party Assurance: Not disclosed

UN Sustainable Development Goals

• Not disclosed

Not disclosed

Sustainable Products & Innovation

• Not disclosed

Awards & Recognition

• Not disclosed

Environmental Metrics

ESG Focus Areas

• Corporate Responsibility
• Sustainability
• Diversity and Inclusion

Environmental Achievements

• Providing electric vehicle charging stations for employees at corporate headquarters

Social Achievements

• Continuing support for scientific, medical, patient, and local communities; sponsoring local youth programs; supporting patient community needs in response to natural disasters; enabling employee participation in charity events; implementing company-wide diversity initiatives, including a Dialogue on Diversity program; partnering with LGBTQ professional groups and local organizations to access diverse talent; establishing key working relationships with local universities to build diversity in the internship program.

Governance Achievements

• Strengthening consideration of diversity factors when evaluating potential director nominees; engaging a third-party advisory firm to conduct the 2022 Board and committee self-evaluation; adopting a compensation recovery (clawback) policy; adopting a Related Person Transaction Policy.

Climate Goals & Targets

Environmental Challenges

• Maintaining a competitive position by attracting, retaining, and motivating key employees with experience and ability in a challenging talent market; balancing equity compensation needs against dilutive effects on stockholders; managing the dilutive impact of the equity award program.

Mitigation Strategies

• Implementing competitive total compensation and benefits; amending the 2022 Equity Incentive Plan to increase the share pool; carefully managing the equity compensation program by reviewing market data and ensuring competitive pay packages; implementing performance-based RSUs (PSUs); adopting a clawback policy.

Supply Chain Management

Climate-Related Risks & Opportunities