Climate Change Data

Environmental Metrics

ESG Focus Areas

• Patient Access
• Community Engagement
• Research and Development
• Employees and Culture
• Environmental Sustainability
• Governance and Integrity

Environmental Achievements

• Initiated a composting program diverting approximately 20,000 pounds of compostable material in 2019 (suspended in 2020, reinstated mid-2021)
• Installed high-efficiency LED lighting with automatic shut-off timers and motion sensors
• Implemented systems to improve HVAC system efficiency in laboratories
• Implemented paper management efforts including recycling and electronic contract management

Social Achievements

• Created YourBlueprint®, a comprehensive patient support program, assisting patients access commercially available medicines and minimizing out-of-pocket costs
• Launched early access programs for investigational therapies
• Partnered with disease experts and patient advocacy groups to create patient registries and surveys (e.g., Touchstone initiative for SM)
• Initiated a sponsored testing program with Labcorp to provide no-charge KIT D816V testing to eligible patients
• Created a Patient Council program involving patients advising on program strategy and clinical trial design
• Received the Top Workplaces USA award from Energage and multiple other awards recognizing equity, diversity, and inclusion practices
• Implemented a hybrid work model (Blue Flex) to improve employee well-being and productivity
• Maintained a voluntary turnover rate below the industry average

Governance Achievements

• Established a Corporate Responsibility Working Group and expanded the Nominating and Corporate Governance Committee’s oversight to include corporate responsibility and ESG matters
• Adopted a Code of Business Conduct and Ethics and a Comprehensive Compliance Program
• Appointed a Chief Compliance Officer and a global Compliance Committee
• Held the first annual Integrity Day to foster a culture of accountability and ethical behavior
• Implemented robust data privacy policies and procedures, including annual training for employees

Climate Goals & Targets

Environmental Challenges

• COVID-19 pandemic impacting patient access to therapies and clinical trials
• Ensuring equitable access to therapies and clinical trials for all patients

Mitigation Strategies

• Implemented practices and procedures to ensure continued patient access to therapies during the pandemic (e.g., local lab testing, home delivery of study medication, remote data monitoring)
• Created a clinical trial travel support program to remove financial barriers to participation
• Provided translation of study materials and partnered with patient advocacy groups to increase diversity in clinical trials

Supply Chain Management

Responsible Procurement

• Robust program for supplier selection and qualification, aligning with cultural values, promoting diversity, equity, and inclusion, and holding partners to high ethical, social, and environmental standards

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: SASB (Sustainability Accounting Standards Board)

Awards & Recognition

• 2022 Top Workplaces USA (Energage)
• 2021 Top Workplaces USA Culture Excellence Award - DE&I Practices (Energage)
• 2021 Top Workplaces USA Culture Excellence Award – Top Managers (Energage)
• 2021 Top Workplaces USA Culture Excellence Award – Compensation (Energage)
• 2021 Technology Fast 500™ Recipient (Deloitte LLP)

Environmental Metrics

ESG Focus Areas

• Corporate Governance
• Commitment to Patients
• Employees and Culture
• Environmental Sustainability

Environmental Achievements

• Developed an Environmental Statement to guide environmental practices.
• Diverted 1,100 pounds of plastic from labs away from landfills and incineration.

Social Achievements

• Recognized as a Top Place to Work in Massachusetts by the Boston Globe and received the Top Workplaces USA award.
• Ranked third for executive gender diversity and ninth for board gender diversity among the 75 largest companies in Massachusetts.
• Launched a Bias Interrupter program to increase equity in performance review cycles.
• Approximately 30% of AYVAKIT medication provided for free to eligible patients in 2022.

Governance Achievements

• Refreshed the Board of Directors with the addition of two new independent members.
• Implemented an overboarding policy.
• Adopted an average tenure goal of 10 years or less for independent directors.
• Implemented shareholder proxy access provisions in bylaws.
• Strengthened ethical business practices with an extensive assessment and update of the Code of Business Conduct and Ethics.

Climate Goals & Targets

Environmental Challenges

• Understanding and capturing metrics reflective of environmental impact.
• Increasing diversity in clinical trials.
• Ensuring broad patient access to innovation.

Mitigation Strategies

• Focusing efforts on releasing an Environmental Statement.
• Providing translation of study materials and partnering with patient advocacy groups.
• Initiating global pre-approval access programs and designing a robust U.S. patient support program.

Supply Chain Management

Responsible Procurement

• Code of Business Conduct and Ethics
• Procurement Policy outlining ethical standards and fair-trade practices
• Robust program for supplier selection and qualification

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: SASB (now under ISSB)

UN Sustainable Development Goals

• Goal 3: Good Health and Well-being
• Goal 4: Quality Education
• Goal 10: Reduced Inequalities

Blueprint's business strategy, products, and services contribute to these goals through various initiatives described in the report.

Awards & Recognition

• Top Place to Work in Massachusetts (Boston Globe)
• Top Workplaces USA award

Environmental Metrics

ESG Focus Areas

• Patient access
• Employee engagement
• Responsible business practices

Environmental Achievements

• Recycled 1,671 pounds of plastic from our Cambridge lab facility in 2023.

Social Achievements

• Named one of the best places to work in Massachusetts by The Boston Globe and recognized as one of the Top Workplaces in the U.S. by Energage for the third year in a row.
• Implemented our global Lifestyle Spending Account to provide for the diverse needs of our employees.
• Gathered and are acting on employee feedback through our Engagement & Enablement Survey, which received a 97% participation rate.

Governance Achievements

• Enhanced clinical trial data cleaning, management and reporting to improve efficiency.
• Provided guidance to our employees on the acceptable use of artificial intelligence and updated our Acceptable Use Policy.
• Offered company-wide training on generative AI.

Climate Goals & Targets

Environmental Challenges

• Climate-related risks, such as natural disasters, could disrupt our facilities, labs, clinical trial sites or the manufacturing facilities of our third-party contract manufacturers and adversely impact our business.

Mitigation Strategies

• We currently assess the impact of climate-related risks as part of our enterprise risk management process.

Supply Chain Management

Responsible Procurement

• Robust program for supplier selection and qualification, aligning with cultural values, promoting ED&I, and holding partners to high ethical, social, and environmental standards.

Climate-Related Risks & Opportunities

Physical Risks

• Natural disasters

Reporting Standards

Frameworks Used: SASB Standards (now part of the IFRS Foundation), UN Sustainable Development Goals (SDGs)

UN Sustainable Development Goals

• Goal 3: Ensure healthy lives and promote well-being for everyone at all ages
• Goal 4: Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all
• Goal 9: Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
• Goal 10: Reduce inequality within and among countries

Alignment described in the report's SDG section.

Awards & Recognition

• Finalist for Transformational Therapy of the Year
• Finalist for ED&I Initiative (only biotech company short-listed)
• #18 on Newsweek's Most Trustworthy Companies in America List