Climate Change Data

Environmental Metrics

ESG Focus Areas

• Social Impact
• Responsible Investing
• Employee Empowerment
• Responsible and Ethical Business

Environmental Achievements

• 100% of electricity supplied to headquarters is generated by wind, solar, or hydro renewable schemes.
• Office space has a zero-to-landfill waste policy, with approximately 60% of waste recycled.

Social Achievements

• Developed treatments improving patients' lives in areas of high unmet medical need.
• Supported UK life science industry by creating jobs and fostering innovation.
• Donated £4.7m to The Syncona Foundation and The Institute of Cancer Research in 2021.

Governance Achievements

• Established a Sustainability Policy and Responsible Investment Policy.
• Implemented key compliance policies (anti-fraud, bribery, data protection, etc.).
• Zero tolerance approach to modern slavery and human trafficking.

Climate Goals & Targets

Environmental Challenges

• High cost of developing complex treatments for small patient groups.
• Ensuring access to medicines for underrepresented groups.
• Minimizing environmental impact of business travel.

Mitigation Strategies

• Working with portfolio companies to develop strategies for broader patient access.
• Encouraging ethical and transparent business practices in portfolio companies.
• Significant reduction in business travel due to COVID-19 pandemic; future targets to reduce emissions.

Supply Chain Management

Supplier Audits: Not disclosed

Responsible Procurement

• Ethical considerations (carbon footprint, regulatory compliance) in due diligence and monitoring.

Climate-Related Risks & Opportunities

Physical Risks

• Not disclosed

Transition Risks

• Not disclosed

Opportunities

• Not disclosed

Reporting Standards

Frameworks Used: GRI Standards: Core option

Certifications: Null

Third-party Assurance: Not disclosed

UN Sustainable Development Goals

• Goal 3
• Goal 8
• Goal 9

Aligned with UN SDGs through focus on health, economic growth, and innovation.

Sustainable Products & Innovation

• Not disclosed

Awards & Recognition

• Not disclosed

Environmental Metrics

ESG Focus Areas

• Patient impact
• Responsible investing
• Employee development and wellbeing
• Responsible and ethical business practices
• Environmental impact

Environmental Achievements

• First full portfolio carbon footprint disclosed (17,901.5 tCO2e)
• Became a signatory to the Net Zero Asset Managers (NZAM) initiative.

Social Achievements

• £4.6m donated to charity
• Launched first Employee Engagement Survey (92% response rate)
• Top 10 firm in FTSE 250 for appointing women to board and leadership positions
• Developed first D&I framework

Governance Achievements

• Implemented new Diversity and Inclusion Framework
• Published full portfolio carbon footprint
• Updated Sustainability and Responsible Investment Policies

Climate Goals & Targets

Environmental Challenges

• Limited direct environmental impact
• Need to improve sustainability reporting from portfolio companies
• Maintaining high standards across a growing and diverse portfolio

Mitigation Strategies

• Collaboration with portfolio companies to collect and report environmental data
• Providing support and guidance to portfolio companies on sustainability
• Integrating responsible investment approach into new company launch process
• Implementing updated Responsible Investment Policy

Supply Chain Management

Responsible Procurement

• Ethical procurement policies
• Consideration of carbon footprint and regulatory compliance in due diligence

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: GRI Universal Standards, TCFD

UN Sustainable Development Goals

• Goal 3
• Goal 8
• Goal 9
• Goal 13

Syncona's activities align with these SDGs through its focus on healthcare, economic growth, innovation, and climate action.

Environmental Metrics

ESG Focus Areas

• Our social impact
• A responsible partner and investor
• Inspiring and empowering our people
• A high quality, responsible and ethical business

Social Achievements

• Charitable donations of 0.35% of group Net Asset Value (NAV) annually via the Syncona Foundation.
• Supporting the UK life science community by creating jobs and wealth.

Governance Achievements

• Strong, open and transparent governance.
• Integration of sustainability issues into investment and management processes.
• Support for portfolio companies to establish appropriate governance and monitoring processes for sustainability performance.

Climate Goals & Targets

Environmental Challenges

• Minimising environmental impact
• Supporting portfolio companies in managing sustainability challenges

Mitigation Strategies

• Portfolio companies to start data collection of Scopes 1 and 2 emissions, and develop Scope 3 data collection strategy.
• Working with portfolio companies to share best practice in tracking and reducing carbon emissions.
• Providing standard policies and materials to portfolio companies to support best practice.

Supply Chain Management

Responsible Procurement

• Ethical Procurement

Climate-Related Risks & Opportunities

Environmental Metrics

ESG Focus Areas

• Responsible Investing
• Social Impact (Patient Focus)
• Inspiring and Empowering People
• Responsible and Ethical Business

Environmental Achievements

• SIML became a signatory of the Net Zero Asset Managers (NZAM) initiative and published its first interim net zero target for 2030.
• Increased carbon emissions data gathered across the strategic portfolio, including employee commuting emissions.

Social Achievements

• Autolus filed a BLA application with the US FDA for its lead therapy.
• Donation of 0.35% of NAV to The Syncona Foundation (£4.4 million).
• Launched the Syncona Fellowship program.
• Increased engagement with the broader UK life science community.

Governance Achievements

• First submission to the UN Principles for Responsible Investment (UN PRI).
• Full integration of responsible investment approach into new company launch process.
• Implementation of updated Responsible Investment Policy in management of capital pool and other life science investments.
• Introduction of 13 new compliance and governance policies across the portfolio.

Climate Goals & Targets

Environmental Challenges

• Challenges in accessing risk capital at the appropriate scale for UK biotech companies.
• Increased business travel leading to higher emissions.

Mitigation Strategies

• Supporting the aims of the Mansion House reforms to increase investment from UK pension funds.
• Purchasing carbon credits to offset operational emissions.
• Focusing on reducing emissions within Syncona’s more mature portfolio through the NZAM initiative.

Supply Chain Management

Responsible Procurement

• Ethical Procurement Policy implemented in some portfolio companies.

Climate-Related Risks & Opportunities

Reporting Standards

Frameworks Used: GRI Universal Standards

UN Sustainable Development Goals

• Goal 3
• Goal 8
• Goal 9
• Goal 13

Syncona's investment strategy aligns with these goals through its focus on developing transformational treatments, fostering innovation, and promoting sustainable economic growth.